Joey Bosa, a Los Angeles Chargers edge rusher, and Rashawn Slater, a left tackle, were both put on injured reserve on Wednesday.
In the opening frame of Sunday's 38-10 loss to the Jacksonville Jaguars, Bosa tore his groyne.
Derwin James Jr., a safety, said, "It's a tough loss for our defence, but it's on us to have his back and hold things down until he gets settled.
The four-time Pro Bowl selection Bosa will have surgery, but coach Brandon Staley says he should be back this year.
In order to add depth, the Bolts also grabbed outside linebacker Derrek Tuszka off of waivers on Tuesday.
Bosa has 59.5 sacks in seven seasons and 1.5 sacks in three games this year.
Salyer, a sixth-round pick, played left tackle in his final two seasons at Georgia, where he helped the Bulldogs win a national championship last January.
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